Nonspecific interstitial pneumonia (NSIP) is a chronic interstitial lung disease characterized by homogeneous expansion of the alveolar walls by inflammation or fibrosis or both. NSIP is the second most common chronic interstitial pneumonia, after usual interstitial pneumonia (UIP), accounting for 14% to 35% of cases.

If no underlying cause is present it is known as idiopathic NSIP. Clinical features (typical) of the idiopathic form: Middle-aged, never-smoker women. Dyspnea. Cough. Ground glass on HRCT. Very good prognosis. Gross/Radiology. No honeycombing. Fibrosis usually lower lung zone. Patchy ground glass. Microscopic. Features: Diffuse fibrosis:

GPA- parenkymblödning 70 -årig man , aldrig rökt, dyspné hosta, sakta sjunkande lungfunktion. 2010. NSIP nonspecific interstitial p. GG, retikulärt mönster/intralobulära linjer, Lynch DA, Travis WD, Muller NL et al Radiology 2005: 236:10-21 Idiopathic interstitial 1Department of Radiology, University of Chicago Medicine, 2Department of Lungfunktionstester används för att bedöma svårighetsgraden av ILD och övervaka dess kurs. NSIP = icke-specifik interstitiell lunginflammation.

If airway-centric disease has been ruled out and interstitial lung disease is suspected, making the distinction between fibrosing and non-fibrosing interstitial lung disease is imperative to narrow the differential diagnosis. 10 Once it has been established that the underlying disorder is fibrotic in nature, the Knowledge of the lung anatomy is essential for understanding HRCT. The interpretation of interstitial lung diseases is based on the type of involvement of the secondary lobule. The secondary lobule is the basic anatomic unit of pulmonary structure and function. It is the smallest lung unit that is surrounded by connective tissue septa. Se hela listan på radiopaedia.org gree of inflammation and fibrosis.

Cellular and fibrotic NSIP are the two main histologic subtypes and differ from one another in the de- gree of inflammation and fibrosis. Nonspecific interstitial pneumonia (NSIP) has variable clinical, pathologic, and radiologic manifestations. Cellular and fibrotic NSIP are the two main histologic subtypes and differ from one another in the degree of inflammation and fibrosis.

Fibrotic non-specific interstitial pneumonitis is a histological subtype of non-specific interstitial pneumonitis (NSIP). It is considered the more common form 1 . This pattern manifests as chronic interstitial inflammation obscured by interstitial fibrosis (with dense collagen), a temporal homogeneous pattern, and occasional focal honeycomb fibrosis 3 .

Very good prognosis. Gross/Radiology.

NSIP is temporally and spatially homogeneous, while UIP is typically heterogeneous, patchy, and irregular in size. 36 The extent of honeycombing and traction bronchiectasis is greater in UIP than the extent of ground glass opacity or micronodules, which are …

Fibrotic NSIP (fig 1 B): The fibrotic type has a preserved architecture.

In this study of patients with histologically well defined UIP and NSIP we found that: (1) patients with an HRCT pattern of UIP are likely to have a histopathological pattern of UIP, but patients with an HRCT pattern other than UIP may have either a histological pattern of UIP or NSIP on the surgical lung biopsy specimen; (2) HRCT features add prognostic information to the histological Thus, using the classification scheme described by Katzenstein and Myers , findings consistent with NSIP were found in 18 of 22 (81.8%) of the surgical lung biopsies. Pulmonary Function Impairment of pulmonary function was predominantly restrictive, with total lung capacity 67.6 ± 14.0% (mean ± SD) predicted, and was below 80% of the predicted value in 27 of 33 patients tested. 2021-04-09 · At our division, we are often dealing with patients with a “typical” phenotype of idiopathic NSIP, as it has now been described , such as a middle-aged never-smoker woman, presenting with dyspnea and cough of 6 to 7 months duration, with a restrictive ventilatory pattern, with bilateral, symmetric, predominantly lower lung reticular opacities at HRCT and diffuse ground glass, without any Idiopathic, nonspecific interstitial pneumonia (NSIP) is most often associated with various clinical disorders, including connective tissue diseases (CTDs) and chronic hypersensitivity pneumonitis (cHP). Emerging evidence also suggests that “idiopathic” NSIP may be the lung manifestation of undifferentiated CTD (UCTD). However, whether or not NSIP outcome is influenced by the underlying Organizing pneumonia is caused by inflammation 10 and may be idiopathic in nature, termed cryptogenic organizing pneumonia, or may occur secondary to infection, collagen vascular disease, or drug toxicity. 35 Organizing pneumonia is characterized by the presence of consolidation and may also show features of fibrosis reminiscent of NSIP.
Tagit hand om

Pathologically and radiologically, NSIP is characterized by two patterns of lung involvement.

11 Oct 2017 Nonspecific interstitial pneumonia (NSIP) • NSIP representing cases of idiopathic interstitial pneumonia that cannot be classified as UIP, DIP, or The diffuse parenchymal lung diseases (DPLDs), also called interstitial lung or an NSIP pattern on imaging, as radiological and pathological correlation is NSIP is the commonest pattern of CTD-related ILD, with systemic sclerosis the radiologic pathology archives: organization and fibrosis as a response to lung 15 Jul 2019 Nonspecific interstitial pneumonia (NSIP) is one type of idiopathic Pulmonary drug toxicity: radiologic and pathologic manifestations.
Download lexin.nada.kth.se

It is thus not currently excluded that NSIP is a somewhat different response by the lung to one and the same triggering mechanism. This is also supported by the differentiation already discussed between the cellular and fibrotic NSIP, in which fibrotic NISP may indeed have a clinical course that resembles IPF, while cellular NSIP often responds to steroids and prognostically is much more

Associated Findings.

"Radiology at a Glance" [9781405192200], Akut internmedicin 2012 (SLL), Skelettmalignitet (myelom, osteosarkom, metastas från bröst-, prostata-, lung-

However, the subpleura is relatively normal in this case, and this patient’s disease has a central, bronchovascular distribution, which is the hallmark feature of NSIP … Quiz: Differentiating Between Chronic HP, NSIP, A Radiology Perspective TLC, total lung capacity. Images courtesy of and used with permission from Jonathan Goldin, MD, PhD. Which of the following features are present in the above axial and coronal HRCT scans? A Honeycombing. 2017-11-29 2015-03-01 fine reticulation.

The secondary lobule is the basic anatomic unit of pulmonary structure and function. It is the smallest lung unit that is surrounded by connective tissue septa. fine reticulation. reticular opacities and irregular linear opacities (sometimes – minor subpleural reticulation).